B-Vitamin Supplement Doesn't Lower Colorectal Cancer Risk - Cancer

Basic InformationMore InformationLatest NewsB-Vitamin Supplement Doesn't Lower Colorectal Cancer RiskObesity Helps Spur Cancer's Growth, Mouse Study SuggestsAbraxane Approved to Treat Advanced Lung CancerGene Signature Validated for Oral Cancer Metastases'Believing' Propels Cancer Survivors to Exercise, Study FindsService That Speeds Up Breast Cancer Diagnosis Pays Off: StudyStudy Confirms Link Between Analgesic Use, Ovarian CancerBlood Test May Spot Rare Lung CancerMelanoma Odds Doubled for Transplant, Lymphoma Patients: StudyScientists ID 'Genetic Signatures' for Aggressive Prostate CancerScientists Link Gene to Lower Risk of Lung CancerMore Stomach, Esophageal Cancers Seen in AIDS Patients Than OthersHeavy Smokers, Drinkers May Face Pancreatic Cancer Earlier in LifeSurvivor of Aggressive Breast Cancer Stresses Need for Quick ActionRare Breast Cancer Poses New Set of ChallengesIndoor Tanning Causes Common Skin Cancers, Study FindsNew Database IDs Variants Linked to Colorectal CancerStudy: Digital Beats Film Mammography at Spotting Breast CancerImaging Method Can Assess Solid Tumor AggressivenessMight Smallpox Virus Help Fight a Lethal Breast Cancer?Novel Drug Approach Shows Promise Against Breast CancerNew Melanoma Treatment Might Delay Cancer ProgressionBreast Cancer Drug Linked to Sexual Problems in Older WomenQuick Survey May Pick Up Ovarian Cancer Warnings: StudyStivarga Approved for Advanced Colorectal CancerWhen Clinically Indicated, Chemo Use High for Breast CancerYoung Cancer Survivors Say Costs Hinder Follow-Up CareStudy Links Another Gene Variant to Male Breast CancerGene Study Yields New Clues to Breast CancerPoorer Patients Find Thyroid Cancer at Later Stage: StudyDrug Class Unexpectedly Effective on Breast CancersNew Guidelines Issued for Pediatric Fever and NeutropeniaBiomarkers Identified in Head and Neck CancersFirst Ultrasound to Spot Cancer in Dense Breasts ApprovedLeast Aggressive Breast Cancer Still Poses Long-Term Risk, Study FindsCancer Overtakes Heart Disease as Top Cause of Death Among U.S. HispanicsNewly Approved Imaging Agent Helps Find Prostate CancerGenomic Alterations ID'd in Lung Squamous Cell CarcinomaSome Screens Miss Spread of Breast Cancer: StudySupportive Spouse May Extend Cancer SurvivalYoung Children Treated for Cancer May Be at Risk for PTSD: StudyPot Use May Raise Risk of Testicular Cancer: StudyPan-Fried Red Meat May Raise Prostate Cancer Risk: Study'Chemo Brain' After Breast Cancer Backed by StudyX-Rays May Up Breast Cancer Risk for Women With Certain Genes: StudyProne-Position Breast Radiation Avoids Heart, Lung ExposureAnthracycline, Trastuzumab for Breast CA Up Heart Failure RiskBosulif Approved for Rare LeukemiaFew Doctors Discuss Exercise With Cancer Patients: StudyAdvanced-Stage Cancer Patients Often Reluctant to ExerciseLinksBook Reviews Updated: Oct 15th 2012 MONDAY, Oct. 15 (HealthDay News) -- A combination of folic acid and vitamins B6 and B12 supplementation does not reduce the risk of colorectal adenoma among high-risk women, according to a study published online Oct. 12 in the Journal of the National Cancer Institute. To examine the effect of combined B-vitamin treatment on the occurrence of colorectal adenoma, Yiqing Song, M.D., of Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues conducted a randomized, double-blind, placebo-controlled trial involving 5,442 women at high risk for cardiovascular disease who were randomized to receive a combination of folic acid (2.5 mg), vitamin B6 (50 mg), and vitamin B12 (1 mg) or placebo. Of these, 1,470 women were followed for as long as 9.2 years and underwent an endoscopy during follow up. The researchers found that there was a similar risk of colorectal adenoma for those receiving combination treatment (24.3 percent) and those receiving placebo (24.0 percent). No statistically significant differences were observed on the basis of adenoma site, size, stage, or number. Alcohol intake, adenoma cancer history, or baseline plasma folic acid/vitamin B6, B12 levels did not affect the results. "In conclusion, data from this study within a large, randomized, placebo-controlled trial indicate no apparent benefit or harm of combined folic acid, vitamin B6, and vitamin B12 supplementation on the risk of colorectal adenoma among women," the authors write. "Our findings do not support recommending B-vitamin supplementation for the prevention of colorectal adenomas." Study supplements and placebos were provided by the chemical companies BASF and Cognis. Abstract Full Text (subscription or payment may be required) Editorial (subscription or payment may be required) This article: Copyright ? 2012 HealthDay. All rights reserved.

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